EVALUATION OF ETHOSOMAL EPIGALLOCATECHIN-3-GALLATE GEL FORMULATIONS AS AN ANTIOXIDANT AND THERMOGENIC AGENT

Objective: The aim of this study was to investigate in vitro and in vivo behavior of the prepared ethosomal formulations of green tea extract, which in turn would result in enhancing their therapeutic efficacy as antioxidants and thermogenic agents in obese mice. Methods: Fat Wistar rats were acclimated for at least 7 d in environmentally controlled cages, then they were divided into five groups: 1st received only distilled water, 2nd received an oral dose of green tea extract, in 3rd group green tea extract loaded gel base was applied on the previously shaven dorsal side of rats and in the other 2 groups selected green tea extract loaded Ethosomal gel base were applied on the previously shaven dorsal side of rats. Total antioxidant capacity by ferric reducing ability of plasma (FRAP) method, catalase enzyme activity, malondialdehyde (MDA) and thiobarbituric acid reactive substance (TBARs) levels, and real-time qPCR of UCP2 and 3 were then determined. Results: Formulation of green tea extract as ethosomal preparations exhibited a controlled release rate due to the reservoir action of ethosomes. The levels of TBARs and MDA were lower in groups supplemented with green tea extracts compared to control group and in groups (3-5) received it transdermal (P<0.0001 in all 3 groups) was lower than group received it orally with P = 0.0081. The messenger RNA levels of UCPs 2 and 3 in BAT were increased in those 3 groups. Conclusion: The results support the efficiency of ethosomal gel in penetrating the lipid rich biological membrane. The in vivo study confirms the antioxidant and thermogenic behavior of transdermal applied green tea extract

Data Mining in Internet of Things Systems: A Literature Review

The Internet of Things (IoT) and cloud technologies have been the main focus of recent research, allowing for the accumulation of a vast amount of data generated from this diverse environment. These data include without any doubt priceless knowledge if could correctly discovered and correlated in an efficient manner. Data mining algorithms can be applied to the Internet of Things (IoT) to extract hidden information from the massive amounts of data that are generated by IoT and are thought to have high business value. In this paper, the most important data mining approaches covering classification, clustering, association analysis, time series analysis, and outlier analysis from the knowledge will be covered. Additionally, a survey of recent work in in this direction is included. Another significant challenges in the field are collecting, storing, and managing the large number of devices along with their associated features. In this paper, a deep look on the data mining for the IoT platforms will be given concentrating on real applications found in the literatur

Synthesis and Characterization of Some Metal Complexes of [4-Methoxy-N-(pyrimidine-2-ylcarbamothioyl)benzamide]

A new ligand [4-Methoxy -N-(pyrimidine-2-ylcarbamothioyl) benzamide] (MPB) was synthesized by reactioniofi(4-Methoxyibenzoyliisothiocyanate)withi(2-aminopyri-midine). The Ligand was characterized by elemental micro analysis (C.H.N.S),(FT-IR) (UV- Vis) and (1Hi,13CNMR)spectra. Some transition metals complexes of this ligand were prepared and characterized by (FT-IR, UV-Vis) spectra conductivity measurements magnetic susceptibility and atomic absorption. From the obtained results the molecular formula of all complexes was suggested to be [M(MPB)2Cl2] (M+2i=Cu, Mn, Co ,Ni ,Zn ,Cd and Hg),the proposed geometrical structure for all complexes was an octahedral

Effect of Gravel Size and Weir Height on Flow Properties of Gabions

لقد تم دراست العلاقة بين عمق الماء المتجمع امام السداد الحجرية والتصريف القادم من اعالي المجاري المائية في قناة مختبرية. حيث تم دراسة السطح الحر للماء في حالة التدفق الانتقالي وفي حالة الفيضان فوقه. تضمنت الدراسة تأثير ارتفاع جسم السداد الحجرية وخشونة المواد المستخدمه في الانشاء على عمق تدفق المنبع عن طريق اختبار أربعة ارتفاعات مختلفة من الهدارات وأربعة أحجام مختلفة من الحصى. أظهر تحليل النتائج المختبرية أن الانخفاض النسبي في عمق الماء المتجمع امام الهدارات يتراوح ما بين 38٪ و17٪ لنوع الجريان " التدفق خلال " عندما يزداد كل من خشونة المادة والتصريف، وفي نظام "التدفق الانتقالي"، تؤدي زيادة خشونة المواد والتصريف إلى انخفاض متوسط في عمق التدفق النسبي بين 7.6٪ و4.4٪ لارتفاع الهدارات الحجرية 15 سم و30 سم، على التوالي. يبدأ السداد الجرية في العمل كهدار يفيض الماء من فوقه عندما يكون متوسط عمق الماء إلى ارتفاع السداد (H / P) هو 1.19، في حين أن متوسط الزيادة الإجمالية في التصريف نسبة إلى تصريف السد الصلب هو 15 ٪. كما تم أقتراح علاقات تجريبية للتنبؤ بعمق الماء المتجمع أمام السداد الحجرية لكل من أنظمة التدفق الثلاثة. كما تم اقتراح علاقة تجريبية عديمة الابعاد للتنبؤ بمعامل التصريف لهذة السداد وبدقة جيدة.The variation between flow depth generated in front of gabion barrier and flow rate has been studied in open laboratory flume. Flow profiles have been observed for each of "Transition Flow" and "Overflow" regimes. Effects of gabion height and material coarseness on the upstream flow depth are studied by testing four different gabion heights and four different medium aggregate sizes. The analysis of experimental results showed that the relative decrease in flow depth varies between 38% and 17% for "Through Flow" type when material coarseness and discharge increase. In "Transition Flow" regime, increasing material coarseness and discharge causes an average decreases in relative flow depth of 7.6% and 4.4% for gabion heights 15cm and 30cm, respectively. Gabion begins to operate as an overflow weir when the average water depth to the gabion height (H/P) is 1.19. While the overall average increase in discharge relative to solid weir is 15%. Prediction relationships for flow depth upstream the gabion for each of the three flow regimes is suggested. Also, dimensionless relation to predict discharge coefficient are proposed with good accuracy

Properties of Flow through and over Gravel Basket Weir

يؤدي إنشاء هدارات من سلال الحصى في المجاري المائية إلى تراكم المياه أمام هذه المشأت المسامية، ويكون فيها منسوب المياه أقل من تلك التي تتجمع مقدمة الهدارات الصلبة. تتضمن هذه الدراسة، تقديرعمق الماء المتجمع امام هذه الهدارات مع قياس شكل السطح الحر للجريان والتنبؤ بقيمة معامل التصريف من خلال التجارب المختبرية. كما تمت دراسة أربعة أطوال مختلفة من الهدارات (15 ، 20 ، 25 و 30 سم) وأربع خشونات مختلفة من الحصى (1.13 ، 1.58 ، 2.19 و 2.27). وفقًا لذلك، فقد تم اختبارستة عشر نموذجاً في ظروف مختلفة من التدفق الحر. أظهرتحليل نتائج نظام الجريان "التدفق النافذ" أن الزيادة في عرض السد تسبب في زيادة عمق الماء المتجمع امام الهدارات ولجميع درجات الخشونة بنسبة 30٪ بينما تقلل الخشونة من العمق بنسبة 28٪. وفي "التدفق الانتقالي"، يؤدي مضاعفة الطول إلى زيادة عمق التدفق بنسبة 7٪، بينما تؤدي زيادة الخشونة من 1.13 إلى 2.72 سم في انخفاض عمق الجريان بنسبة 7٪. يبدأ نظام "التدفق الفائض" بالظهورعندما تساوي نسبة عمق الماء إلى عرض السد حوالي 0.75 للعرض الكبير و1.54 للعرض القليل. تشير المقارنة بين هدارات سلال الحصى والهدارات الصلبة إلى أن متوسط تقليل عمق الماء هو 7.5٪ للصلابة البالغة 1.13 سم و9٪  للصلابة البالغة 2.72 سم. تم اقتراح نماذج رياضية للتنبؤ بعمق المياه لأنظمة التدفق الثلاثة، أما بالنسبة لنظام "التدفق الفائض"، فقد اقتُرِحَت صيغة تجريبية لتقدير معامل التصريف بدقة مقبولة.Construction of gravel basket weir in waterways causes water accumulation in front of this porous structure less than solid weir. In the present study the upstream flow depth, water surface profile and discharge coefficient are investigated through laboratory experiments. Four different weir lengths (15, 20, 25 and 30 cm) and four different degrees of gravel coarseness (1.13, 1.58, 2.19 and 2.27) are studied. Accordingly, sixteen models are tested under different free flow conditions. Analysis of the results show that in "through flow" regime the increase in weir length raises the generated upstream depth for all coarseness degrees by 30% while coarseness lowers the depth by 28%. In "transition flow", however, doubling the length increases the flow depth by 7%, but increasing coarseness from 1.13 to 2.72 cm mean diameter causes 7% reduction in flow depth. The "overflow" regime begins to appear when the depth to length ratio equals 0.75 for long weir, and about 1.54 for shortest weir. A comparison between gravel basket weir and corresponding solid weir indicates that average depth reduction is 7.5% for coarseness of 1.13 cm and 9% for coarseness of 2.72 cm. Mathematical models for water depth prediction for the three flow regimes are presented. For "overflow" an empirical formula is proposed to estimate the coefficient of discharge with acceptable accuracy

Finite Element Approach for Coupled Striplines Embedded in Dielectric Material

In this paper, we present finite element method (FEM) to investigate the quasi-static analysis of two dimensional (2D) shielded two coupled stripline structures for microelectronic devices. In the proposed method, we specifically determine the values of capacitance per unit length and inductance per unit length of shielded two vertically coupled striplines and shielded two coupled striplines embedded in dielectric material. Extensive simulation results are presented, and some comparative results are given by other methods and found them to be in excellent agreement. Furthermore, we determine the quasi-TEM spectral for the potential distribution of these shielded two coupled striplines

An Analytical Approach for Mobility Load Balancing in Wireless Networks

Management of mobility especially balancing the load of handoff for wireless networks is an essential parameter for wireless network design and traffic study. In this paper, we present analytical mobility management in high speed wireless mobile networks focusing on factors such as the number of channel slots and offered load. We demonstrate the performance of handoffs with mobility consideration using several metrics including the alteration of states prior to reaching a cell boundary, the speed of mobile terminal, and the distance between a mobile terminal and a cell boundary. We mainly focus on the performance evaluation for the factor of mobility with taking into account the high speed status of a user